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KMID : 0895420010110020153
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Journal of Korean Society of Occupational and Enviromental Hygiene
2001 Volume.11 No. 2 p.153 ~ p.160
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A study on the renal dysfunction among workers exposed to organic solvent mixtures
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김정원/Kim, Jung Won
백수동/이창희/김정호/강동묵/문덕환/이채언/Paik, Soo Dong/Lee, Chang Hee/Kim, Jung Ho/Kang, Dong Mug/Moon, Deog Hwan/Lee, Chae Un
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Abstract
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Objectives: The authors evaluated the effects on renal function of workers chronically exposed to low-level organic solvent mixtures.
Methods : The authors measured the level of urine β 2-microglobulin(β2-MG) and microalbumin as biochemical markers or renal function and damage in 29 male workers exposed to organic solvents for more than five years and compared their results with those of 30 male office clerks as a reference group.
Results:
1. The mean values of hemoglobin, hematocrit, SGOT, SGPT, γ-GTP were all with in normal limits and there was no significant difference, except for hemoglobin(p<0.01), between exposed and reference group.
2. The value of BUN and serum creatinine were within reference limits and there was no significant difference between exposed and reference group.
3. The difference of mean values of urine microalbumin corrected by urine creatinine were statistically significant(p<0.01), but those of urine β2-MG was not.
4. There were no correlation of urine hippuric acids with BUN, serum creatinine, urine microalbumin and β2-MG.
5. There were no significant difference of BUN, serum creatinine, urine microalbumin and β2-MG upon work duration. Conclusion: It is assumed that chronic low-level organic solvent exposure in these workers shows early renal dysfunction, glomerular changes. The result corresponds to previous studies showing the relationship between hydro-carbon exposure and glomerulonephritis. For evaluation of impairment on kidney tubules, we need further study using more precise markets and long-term follow-up.
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